Impact of the suspension of neurogenic detrusor overactivity treatment with botulinum toxin due to the COVID-19 pandemic.

INTRODUCTION: The COVID-19 pandemic has imposed an additional pressure on health systems worldwide. Patients with neurogenic detrusor overactivity (NDO) were especially vulnerable to inadequate care. This study aims to evaluate the impact of the suspension of NDO treatment with Botulinum Toxin (BONT-A) due to the COVID-19 pandemic. METHODS: Cross-sectional study of patients with spinal cord injury and NDO, who underwent BONT-A treatment in 2018 or 2019 and, whose administration programed for 2020 or 2021 was suspended. The study protocol was divided into two parts. Phase 1 consisted of data collection from the clinical processes and in phase 2 a standardized telephone questionnaire was applied. Information was collected at 3 time points: (1) before the last BONT-A treatment, (2) after the last BONT-A treatment and (3) at the time of the telephone call. Statistical analysis used the McNemar and the Wilcoxon test with a p-value ⩽ 0.05 as level of significance. RESULTS: 21 patients with mean age of 42.0 years and disease duration of 16.9 years were included. On average patients were undergoing treatment with BONT-A for 7.6 years and mean inter-treatment frequency was 2.3 years. Mean time since the last BONT-A administration was 2.3 years and mean reported BONT-A effect duration was 11.9 months. A significant increase in the percentage of patients with involuntary urinary loss (p = 0.004) and urgency (p = 0.031) was found. A significant decrease in mean catheterization interval from 4.5 to 3.6 h (p = 0.002) and an increase in daily oxybutynin dosage from 8.5 to 12.1 mg (p = 0.002) was also found. DISCUSSION: The COVID-19 pandemic originated clinical worsening of patients undergoing regular BONT-A treatment for NDO. These patients presented a significant increase in involuntary urinary loss, urgency and medication dosage and a decrease in catheterization interval. Thus, interruption of intravesical BONT-A treatment severely affected these patients and needs to be avoided.

ERS International Congress 2022: highlights from the Allied Respiratory Professionals Assembly.

In this article, we provide a brief overview of some of the outstanding sessions that were (co)organised by the Allied Respiratory Professionals Assembly during the 2022 European Respiratory Society International Congress, which was held in a hybrid format. Early Career Members from Assembly 9 summarised the content of the sessions, with the support of the Officers from the four Assembly groups: Respiratory Function Technologists and Scientists (Group 9.01); Physiotherapists (Group 9.02); Nurses (Group 9.03); and Psychologists and Behavioural Scientists (Group 9.04). The sessions covered the following topics: recent advances in cardiopulmonary exercise and challenge testing; the role and new trends in physiotherapy, exercise and physical activity promotion interventions in chronic respiratory diseases; development of the international curriculum for respiratory nurses and nursing aspects in disease management; and treatment adherence, e-health interventions and post-coronavirus disease 2019 challenges. This Highlights article targets delegates who attended the Congress sessions, as well as those who were unable to attend, and provides valuable insight into the latest scientific data and emerging areas affecting the clinical practice of Allied Respiratory Professionals.

COVID-19: Financial Stress and Well-Being in Families.

In all areas of knowledge, research has shown the devastating effects of COVID-19, and the impact on families' financial stress and well-being is one of them. Crises are predictors of families' financial stress as they produce changes in their income and negative feelings, such as fear and demotivation, which affect well-being. This study analyses the financial and social impact of COVID-19 on families, supported by the ABCE-WB model, with data collection being the result of snowball sampling. The results obtained allow the conclusion that the current pandemic crisis has caused financial stress in families, to a greater or lesser degree, and caused feelings of fear and demotivation as consequences of the general lockdown. The empirical evidence also shows that these effects are positively associated with the perception of their level of well-being. The contribution of the study lies in corroborating the model used. Final considerations are presented together with the limitations and suggestions for future research.

How do social responsibility and social entrepreneurship generate value creation in pandemics?

PurposeUsing self-determination theory and individual social responsibility's (ISRs) association with pure social entrepreneurship, this study aims to answer the following question: How and why have the different actors responded to the crisis caused by the pandemic?Design/methodology/approachQualitative research (multiple case studies) was adopted, resorting to interviewees with seven economic and non-economic actors in the Portugal context.FindingsThe results obtained, using MAXQDA software, show that those carrying out actions of social responsibility have a high degree of self-determination and intrinsic motivation, and are true social entrepreneurs, which lets them improve the well-being of those around them. In addition, these individuals feel good about themselves by performing these actions, as they measure their performance by the social impact of their actions on society in general.Practical implicationsThis study suggest there is a high awareness amongst people to exercise that responsibility in a voluntary way, through humanitarian initiatives and campaigns brought about especially by an unprecedented pandemic. In practice, people joining these initiatives motivate many others towards the causes, creating the will to continue in the future and satisfy unmet needs provoked by social crises.Originality/valueThis study is innovative because it is related to filling the gaps identified, mainly by carrying out an empirical study about ISR, rather than that of firms, where studies are more common.

Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses.

To address the ongoing SARS-CoV-2 pandemic and prepare for future coronavirus outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV-2 variants and coronavirus lineages is essential. We describe a highly conserved, conformational S2 domain epitope present only in the prefusion core of ß-coronaviruses: SARS-CoV-2 S2 apex residues 980-1006 in the flexible hinge. Antibody RAY53 binds the native hinge in MERS-CoV and SARS-CoV-2 spikes on the surface of mammalian cells and mediates antibody-dependent cellular phagocytosis and cytotoxicity against SARS-CoV-2 spike in vitro. Hinge epitope mutations that ablate antibody binding compromise pseudovirus infectivity, but changes elsewhere that affect spike opening dynamics, including those found in Omicron BA.1, occlude the epitope and may evade pre-existing serum antibodies targeting the S2 core. This work defines a third class of S2 antibody while providing insights into the potency and limitations of S2 core epitope targeting.

Strategy and Human Resources Management in Non-Profit Organizations: Its Interaction with Open Innovation

The socioeconomic changes that many countries have been experiencing in recent decades, caused by structural factors or by specific circumstances, where the pandemic crisis of COVID-19 is only the most recent example, have posed challenges to organizations, which present themselves more and more and in various forms as threatened by the possibility of fulfilling their mission. Public and private sectors increasingly present themselves as insufficient to respond effectively to day-to-day requests. This context of instability and the resulting impacts for non-profit organizations pose serious problems to the way in which governance is exercised and served as a motivation for carrying out a study that aimed to understand the influence of strategy and human resources on the governance of these organizations. A review of the literature on the variables under study made it possible to identify the sub-dimensions associated with each one of them and the respective indicators. Thus, for a quantitative study, it was possible to apply a questionnaire to 242 Holy Houses of Mercy in Portugal to understand the direct and indirect influences of strategic management and human resources management on the governance of these institutions. The results obtained show the existence of a positive relationship between the variables under analysis, confirming that not only do these variables influence, by themselves and directly, the governance of the institutions studied, but also the strategy influences human resources policies, which in turn have implications for the way the Holy Houses of Mercy deal with aspects associated with governance. It is concluded that, in general, for these organizations to be more effective in efforts to improve their governance processes, they must focus on strategic management and human resources management instruments.

SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines.

Numerous safe and effective COVID-19 vaccines have been developed worldwide that utilize various delivery technologies and engineering strategies. We show here that vaccines containing prefusion-stabilizing S mutations elicit antibody responses in humans with enhanced recognition of S and the S1 subunit relative to postfusion S, as compared to vaccines lacking these mutations or natural infection. Prefusion S and S1 antibody binding titers positively and equivalently correlated with neutralizing activity and depletion of S1-directed antibodies completely abrogated plasma neutralizing activity. We show that neutralizing activity is almost entirely directed to the S1 subunit and that variant cross-neutralization is mediated solely by RBD-specific antibodies. Our data provide a quantitative framework for guiding future S engineering efforts to develop vaccines with higher resilience to the emergence of variants than current technologies.

The Developmental Trajectory of Motor Competence of Children That Lived the COVID-19 Confinement Period: A Four-Year Follow-Up Study in Portuguese Children.

Children's motor competence (MC) was negatively affected by the COVID-19 pandemic; however, possible chronic effects have not been studied. Therefore, the aim of this study was to examine the possible impact of the forced lack of physical activity (PA) during the COVID-19 lockdown on children's MC two years later. The motor competence of sixty-seven healthy children (7.4-12.2 years old) was assessed using the Motor Competence Assessment (MCA). All participants completed the MCA tests at two different moments (before and after the COVID-19 lockdown), four years apart. The mean values after the COVID-19 lockdown for all participants on the subscales and on the Total MCA are lower, but no significant changes were found when controlling for gender and age (p > 0.05 in all analyses). However, a significant decrease was found in the Locomotor subscale in boys (p = 0.003). After dividing the participants into three age groups, the youngest also suffered a decrease in the Locomotor subscale (p < 0.001) and their Total MCA (p = 0.04). In addition, those participants who had a higher MC at baseline decreased their scores for the Locomotor (p < 0.001) and Manipulative (p < 0.001) subscales, and for the Total MCA (p < 0.001). In conclusion, the younger children and the more motor proficient did not fully recover from the negative effects of the pandemic lockdown after two years.

Analysis of the Sustainability of Long-Term Detraining Caused by COVID-19 Lockdown: Impact on the Maximal Aerobic Speed of Under-16 Soccer Players

This retrospective cohort study aimed to analyze the effect of a 9-week detraining caused by COVID-19 lock-down on the maximal aerobic speed (MAS) of youth soccer players. The study included twenty-two under-16 male players competing at the national league level (15.4 ±0.7 years old) who were analyzed pre and post the detraining period. The MAS was estimated using the Bronco's test. Moreover, the self-regulated physical exercise performed by the players during the lockdown was monitored using a questionnaire. Considering the training volume per week, the players were grouped into those working more (>180 min/week) and those working less (<180 min/week) during the lockdown. Within-group changes revealed no significant differences (p = 0.122;d = 0.381) in the group that self-trained less than 180 min/week started (pre-lockdown) at 3.97 ±0.29 m/s and ended (post-lockdown) at 3.85 ±0.34 m/s, corresponding to a decrease of 3.02%. For those who self-trained more than 180 min/week during the lockdown, they started with 4.33 ±0.28 m/s and decreased by 1.62% for 4.26 ±0.28 m/s (p = 0.319;d = 0.250). The team as a whole (pooled data, all players included) decreased 2.27% from 4.15 ±0.34 to 4.06 ±0.37 m/s (p = 0.077;d = 0.321). Between group analysis revealed that the group of players that trained more than 180 min/weeks were significantly better than players working below 180 min/week in both pre-lockdown moment (+9.01%;p = 0.007;d = 1.263) and post-lockdown moment (10.6%;p = 0.006;d = 1.323). Home-based training can be a good strategy to mitigate the detraining effects caused by a lockdown.

Alkali-Activated Materials with Pre-Treated Municipal Solid Waste Incinerator Bottom Ash

This study presents the results of an experimental campaign on the use of municipal solid waste incinerator bottom ash (MIBA) and fly ash (FA) as precursors for the production of alkali-activated materials. MIBA was subjected to a pre-treatment stage in response to two issues: high metallic aluminum content, which reacts in a high pH solution, releasing hydrogen;and low amorphous content of silica-, aluminum- and calcium-bearing phases, which translates into a limited formation of reaction products. The proposed pre-treatment stage oxidizes most of the metallic aluminum fraction and compensates for the low reactivity of the material via the formation of additional reactants. Different combinations of MIBA and FA were tried—mass-based ratios of 0/100, 25/75, 50/50, 75/25, and 100/0 for MIBA/FA. Two mix designs of the alkaline activator with sodium hydroxide and sodium silicate were evaluated by varying the Na2O/binder and SiO2/Na2O ratios. These mortars were tested in the fresh and hardened state. The results showed that the pre-treatment stage was effective at stabilizing the dimensional variation of MIBA. Despite the lower reactivity of MIBA, mortars with 50/50 of MIBA/FA presented a maximum 28-day compressive strength of 25.2 MPa, higher than the 5.7 MPa of mortars made with MIBA only.

Reviewing COVID-19 Literature on Business Management: What It Portends for Future Research?

Who could have imagined that the COVID-19 crisis would affect the whole world? This means that all aspects of society, in general, have felt the consequences of the measures imposed to reduce contagion. Firms, businesses, and their management had to be and must continue to be resilient, and entrepreneurs creative to overcome the present and future impacts of the pandemic, which will be long-lasting. This study aims to map the existing literature on the topic and identify emerging ones. To provide a robust response to this objective, qualitative methodology was adopted through content analysis of the selected documents and the use of MAXQDA software to analyze qualitative data. In addition, a descriptive analysis of the selected documents is presented. The results obtained show there is still a shortage of studies, principally empirical ones, addressing this subject, to complete existing knowledge and thereby contribute to understanding the effects of the virus on businesses and their management. The main contribution of this article lies in a first systematization and coding of the literature, to identify emerging topics for study by academics, the foremost agents of knowledge.

COVID 19 and the Business Management Crisis: An Empirical Study in SMEs

The COVID-19 pandemic has forced many firms to close, causing an unprecedented interruption in trade in most sectors of economic activity worldwide. Although global supply chains have been affected by the general lockdown, due to their particular characteristics, small and medium-sized enterprises (SMEs) have been hit most severely by the measures implemented to prevent the spread of the virus. This study aims to determine how these firms coped with the disruption caused by the closure, in terms of population and their daily lives to carry out their economic activities. For this purpose, a qualitative methodology (descriptive and inductive) was used through the use of snowball sampling with a questionnaire in Portugal during the lockdown. The results obtained show that SMEs face a series of difficulties from interrupting their operations, which has caused serious liquidity problems, with effects on their future continuity and maintaining jobs. Additionally, it showed the importance of government measures to support these firms today and in the future, although the number of firms adhering to them is considerably affected by the eligibility criteria and the speed of institutions’ response. The main contribution of this research lies in confirming that the weaknesses in SMEs are the principal obstacle to a resilient response to this crisis, such as their limited liquidity, human resources, digitalization, and use of information technology. These weaknesses and/or threats had already been indicated in the various theoretical currents stemming from Organizational Theory, so the originality of this contribution lies in the fact that the managers of these SMEs are endowed with other skills and characteristics, such as, for example, dynamic capacities to manage business in an unparalleled crisis and to continue their operations, even when faced with a global blockage. Implications for theory and practice, limitations, and suggestions for future research are also presented.

Selecting lifestyle entrepreneurship recovery strategies: A response to the COVID-19 pandemic

The devastating context of the Covid-19 pandemic has created a new reality in which tourism has practically come to a standstill, a situation that must be reversed. This study focuses on the revitalization of businesses run by lifestyle entrepreneurs, a very significant class, of pivotal importance in innovation in the tourism sector. Specifically, this study aims to identify the most relevant indicators to select the recovery strategies of these entrepreneurs. Using the Delphi method combined with the Q-sort technique, a ranking of the indicators was produced on the basis of input from a panel of 26 senior managers and academics. The top five indicators were: creativity and innovation, level of innovation, qualification, startups number, and turnover volume. Findings reveal that the priority is on innovation and the qualification of the entrepreneurs. Only afterward do the traditional indicators of competitiveness of tourist destinations emerge.

Ionising radiation risk perception through mental models: towards radiological emergency preparedness.

In case of a chemical, biological, radiological, or nuclear emergency, there are recommended or required behaviours to be adopted by the public, e.g. go inside, stay inside, stay informed. The initial response can be crucial to outcomes, all the while recognising that changes may be needed as the emergency progresses. The recent coronavirus pandemic demonstrated how the course of action taken by authorities endorsing these protective behaviours early on can save thousands of lives. Factors that determine response success include public compliance with authorities' recommendations and cooperation between experts and rescuers. In particular, the way rescuers perceive the risks of ionising radiation hazards will influence their preparedness to respond in case of a radiological or nuclear emergency. Having found no previous studies on radiological hazard and risk perception amongst rescuers in Portugal, mental models were used as a descriptive approach. The target groups were firefighters and the military formally trained to deal with radiation hazard emergencies. Their representations of radiological hazards and risks were analysed in the light of an expert model built ad hoc. The results show several overlays between experts and rescuers on the understanding of radiation hazards and potential risks. We conclude that the main gap between radiation risk perceptions by rescuers and experts involves the concepts and mechanisms of radiation contamination and its spread among individuals, in particular, if persons exposed to radioactive sources may also become a radioactive source themselves. This gap can have practical implications for an emergency response.

COVID-19 and Disruption in Management and Education Academics: Bibliometric Mapping and Analysis

COVID-19, What to do now? This issue has had devastating effects in all domains of society worldwide. Lockdowns, the lack of freedom and social distancing meant the closure of a country"s entire activity. Having effects at all levels, beside incalculable ones in health, it is argued that scientific activity in education, business, economics and management suffered some of the most drastic impacts of this pandemic. This study aims to map the scientific literature in these areas in the context of COVID-19 and analyze its content through bibliometrics, which made it possible to highlight the scarcity of studies on the topic, namely empirical studies on the effects of this pandemic on scientific research and teaching/education. The results show there is a lack of peer-reviewed publications on this topic, with the studies covered (93) via the threads used revealing only 28 articles coming within the proposed objective. The bibliometrics corroborates that shortage. Finally, the contributions and implications for theory and practice are presented, followed by the limitations and suggestions for future research.